Автор: Marvin Jens Название: Dissecting Regulatory Interactions of RNA and Protein ISBN: 3319361171 ISBN-13(EAN): 9783319361178 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.
Автор: Marvin Jens Название: Dissecting Regulatory Interactions of RNA and Protein ISBN: 3319070819 ISBN-13(EAN): 9783319070810 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.
Автор: Frank J. Schmidt Название: RNA-RNA Interactions ISBN: 1493941615 ISBN-13(EAN): 9781493941612 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Identifying RNA Recombination Events and Non-covalent RNA-RNA Interactions with the Molecular Colony Technique
Helena V. Chetverina and Alexander B. Chetverin
2. RNA-directed Recombination of RNA in Vitro
Niles Lehman, Nilesh Vaidya, and Jessica A. M. Yeates
3. RNA-RNA Selex
B. Cho
4. Identification of Antisense RNA S0tem-loops that Inhibit RNA-protein Interactions using a Bacterial Reporter System
Kazuo Harada
5. Trans-activation of Large Ribozymes
Matthew B. Martin, Thomas L. Leeper, and Frank J. Schmidt
6. Native Purification and Labeling of RNA for Single Molecule Fluorescence Studies
Arlie J. Rinaldi, Krishna C. Suddala, and Nils G. Walter
7. Single Molecule Studies of RNA-RNA Interactions
Dongmei Yu, Peiwu Qin, and Peter V. Cornish
8. Modification Interference Analysis of the Ribosome
Simpson Joseph
9. Assessing Intermolecular RNA: RNA Interactions Within a Ribonucleoprotein Complex Using Heavy Metal Cleavage Mapping
Keith T. Gagnon and E. Stuart Maxwell
10. Monitoring RNA-RNA Interactions With Electrophoretic Mobility Shift Assays: Analysis Of Trna Binding To The T Box Riboswitch Antiterminator RNA
R. Anupam, S. Zhou, and J.V. Hines
11. Electrophoretic Mobility Shift Assay of RNA-RNA Complexes
Geunu Bak, Kook Han, Kwang-sun Kim, and Younghoon Lee
12. Structural Studies of a Double-stranded RNA from Trypanosome RNA Editing by
Small Angle X-ray Scattering
Angela Criswell and Blaine H.M. Mooers
13. Fusion RNAs in Crystallographic Studies of Double-stranded RNA from
Trypanosome RNA Editing
Blaine H.M. Mooers
Автор: M. Lucrecia Alvarez; Mahtab Nourbakhsh Название: RNA Mapping ISBN: 1493953869 ISBN-13(EAN): 9781493953868 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In RNA Mapping- Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study RNA.
Автор: Ane Sesma; Tobias von der Haar Название: Fungal RNA Biology ISBN: 3319056867 ISBN-13(EAN): 9783319056869 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: RNA polymerase II-dependent transcription in fungi and its interplay with mRNA decay.- Pre-mRNA splicing and the spliceosome: assembly, catalysis and fidelity.- Fungal pre-mRNA 3' end processing.- mRNA export.- mRNA translation: Fungal variations on a eukaryotic theme.- mRNA localization.- mRNA degradation and decay.- Cytoplasmic mRNA surveillance pathways.- Making Ribosomes: pre-rRNA Transcription and Processing.- Biogenesis and evolution of functional tRNAs.- Small RNA-mediated gene silencing in Neurospora.- The RNAi machinery in Mucorales: the emerging role of endogenous small RNAs.- Regulation of pericentric heterochromatin by ncRNA in Schizosaccharomyces pombe.- Approaches for dissecting RNA-binding protein networks.- Bioinformatic tools for Next-Generation RNA sequencing analysis.
Автор: Kathryn Sandberg; Susan E. Mulroney Название: RNA Binding Proteins ISBN: 1441949356 ISBN-13(EAN): 9781441949356 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: RNA binding proteins are an exciting area of research in gene regulation. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.
Описание: This new publication in the Methods in Molecular Biology series sets out detailed protocols for the targeted bioinformatics procedures dedicated to RNA structure. It features practical and algorithmic approaches as well as expert problem-solving advice.
Автор: Volker A. Erdmann; Stefan Jurga; Jan Barciszewski Название: RNA and DNA Diagnostics ISBN: 3319173049 ISBN-13(EAN): 9783319173047 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”
Описание: The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics.
Автор: Mouldy Sioud Название: RNA Therapeutics ISBN: 1493961519 ISBN-13(EAN): 9781493961511 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular Biology™ series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.
Автор: Satoko Yoshizawa Название: Nanotechnology Tools for the Study of RNA,137 ISBN: 0128045655 ISBN-13(EAN): 9780128045657 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume of Progress in Molecular Biology and Translational Science introduces emerging strategies of studying RNA structure and function using nanotechnological tools. The volume aims to provide the readers with a novel view and give them opportunities to think about how to incorporate the new technologies into their own research.
Автор: Eckart Bindewald; Bruce A. Shapiro Название: RNA Nanostructures ISBN: 1493971379 ISBN-13(EAN): 9781493971374 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents a collection of computational and experimental protocols pertaining to the creation, characterization, and utilization of RNA nanostructures.
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