Steroid Receptors in Health and Disease, Virinder Moudgil
Автор: G.A.W. Rook; S. Lightman Название: Steroid Hormones and the T-Cell Cytokine Profile ISBN: 1447112385 ISBN-13(EAN): 9781447112389 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ThI-enhancing effects of another adrenal steroid, dehydroepiandro- sterone sulfate (DHEAS). Second, the activity of cortisol is directly modulated by enzymes in the target organs and lymphoid tissues that convert it into inactive cortisone. This new information leads to the possibility that immunoregulatory steroids could be used by physicians in novel ways. We can envisage steroid combinations that exploit the anti-inflammatory effects of corti- sol, while the Thi-suppressing and Th2-promoting properties of these hormones are opposed by derivatives of DHEAS. Such therapies are already proving effective in animal models of infection, and could revol- utionize treatment of Th2-mediated diseases such as asthma, where the anti-inflammatory effects of cortisol are desirable but the effects on T lymphocyte differentiation are not.
Автор: K. Menon Название: Steroid Hormone Action and Cancer ISBN: 1468426036 ISBN-13(EAN): 9781468426038 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This symposium was organized to bring together basic scientists and clinicians for the purpose of exchanging new ideas and the latest information in the area of Steroid Hormone Action and Cancer.
Описание: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain.
Автор: Veldhuis Название: Sex-steroid Interactions With Growth Hormone.1999 ISBN: 0387988106 ISBN-13(EAN): 9780387988108 Издательство: Springer Цена: 5974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. The proceedings provide new insights and concepts gained by molecular, cellular and neuroendocrine research into mechanistic interactions of the reproductive and somatotrophic axes. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; sex steroids, growth hormone releasing factor, and somatostatin; how sex steroids modulate growth hormone action on target issues; and differential effects of growth hormone secretagogues in men and women. This volume is designed for physicians, scientists and other health professionals interested or trained in clinical and basic endocrinology, growth or reproduction.
Автор: Arun K. Roy; James H. Clark Название: Gene Regulation by Steroid Hormones IV ISBN: 1461281970 ISBN-13(EAN): 9781461281979 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds.
Автор: Arun K. Roy; James H. Clark Название: Gene Regulation by Steroid Hormones III ISBN: 1461291143 ISBN-13(EAN): 9781461291145 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: George P. Chrousos; D. Lynn Loriaux; Mortimer B. L Название: Steroid Hormone Resistance ISBN: 1468451030 ISBN-13(EAN): 9781468451030 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones.
Автор: Castoria Название: Advances in Rapid Sex-Steroid Action ISBN: 1489989358 ISBN-13(EAN): 9781489989352 Издательство: Springer Рейтинг: Цена: 26552.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines how rapid steroid actions not only impact disease development and response to conventional therapies for breast and prostate cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities.
Автор: Ulrich Westphal Название: Steroid-Protein Interactions II ISBN: 3642824889 ISBN-13(EAN): 9783642824883 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents contributions of the Catholic-Lutheran International Conference held at the Pontifical Athenaeum of St. Anselm in Rome in 2016. The scholars were invited to reflect together on the questions of forgiveness, conversion and penance in the context of the ecumenical dialogue that has been going on since the Second Vatican Council.
Автор: Johannes D. Veldhuis; Andrea Giustina Название: Sex-Steroid Interactions with Growth Hormone ISBN: 1461271878 ISBN-13(EAN): 9781461271871 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; how sex steroids modulate growth hormone action on target issues;
Автор: Jack R. Jr. Lancaster; J.F. Parkinson Название: Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones ISBN: 3662035057 ISBN-13(EAN): 9783662035054 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of mammalian nitric oxide (NO-) synthesis from I-ar- ginine has led to profound increases in our understanding of basic physiological and pathophysiological processes. This understanding has been achieved by major advances in several areas. Three major ni- tric oxide synthase (NOS) isoforms have been identified at the protein and gene level and their specific tissue localization has been linked to processes subject to regulation by NO-. The molecular basis for the di- verse effects of NO- on cell function has been shown to derive from its chemical reactivity with oxygen-containing species and both heme and non-heme iron-dependent enzymes. The potential regulation of heme- dependent enzymes such as cytochromes P450, guanylate cyclase, cy- clooxygenase, and mitochondrial cytochrome oxidase continues to emerge as a key area in NO- research. In addition, it has become clear that the expression of NOS isoforms and NO- release from cells is subject to regulation by sexual steroids and that, in tum, NO- has the potential to regulate steroid biosynthesis via inhibition of cytochromes P450 involved in steroidogenesis. These recent observations on interactions between the NO-/NOS and cytochrome P450/sexual steroid pathways have important implica- tions for understanding fundamental mechanisms involved in endocri- nological processes. They are also likely to lead to novel insights and novel therapeutic approaches for the management of pathophysiologi- cal conditions associated with alterations in sexual steroid hormones.
Автор: H.M. Beier; P. Karlson Название: Proteins and Steroids in Early Pregnancy ISBN: 3642678920 ISBN-13(EAN): 9783642678929 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With the collaboration of numerous experts
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
