Tumor Profiling, Sarah S. Murray

Автор: Grutzmann Robert, Pilarsky Christian
Название: Cancer Gene Profiling: Methods and Protocols
ISBN: 1493979973 ISBN-13(EAN): 9781493979974
Издательство: Springer
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Цена: 15998.00 р.
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Описание:

1. Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository
Daniel S. Atherton, Katherine C. Sexton, Dennis Otali, Walter C. Bell, and William E. Grizzle

2. Tissue Microdissection
Anja Rabien and Glen Kristiansen

3. Tissue Microarrays
Ana-Maria Dancau, Ronald Simon, Martina Mirlacher, and Guido Sauter

4. Gene Expression Analysis in the Age of Mass Sequencing: An Introduction
Christian Pilarsky, Lahiri Kanth Nanduri, and Janine Roy

5. Quantitative DNA Methylation in Cancer
Ole Ammerpohl, Andrea Haake, Julia Kolarova, and Reiner Siebert

6. Single Nucleotide Polymorphism to Associate Cancer Risk
Victoria Shaw, Katie Bullock, and William Greenhalf

7: Exosomes in Cancer Disease
Margot Zцller

8: MicroRNAs (miRNAs) Profiling
Lu Gao and Feng Jiang

9. Cancer Gene Profiling for Response Prediction
B. Michael Ghadimi and Peter Jo

10. Target Gene Discovery for Novel Therapeutic Agents in Cancer Treatment
Sanjay Tiwari, Ole Ammerpohl, and Holger Kalthoff

11. Application of Proteomics in Cancer Biomarker Discovery: GeLC-MS/MS
Pedro R. Cutillas and Tatjana Crnogorac-Jurcevic

12. Meta-Analysis of Cancer Gene Profiling Data
Janine Roy, Christof Winter, and Michael Schroeder

13. Reproducible, Scalable Fusion Gene Detection from RNA-Seq
Vladan Arsenijevic and Brandi N. Davis-Dusenbery

14. Transcriptome Sequencing for the Detection of Chimeric Transcripts
Hsueh-Ting Chu

Автор: Espina Virginia
Название: Molecular Profiling: Methods and Protocols
ISBN: 1493983601 ISBN-13(EAN): 9781493983605
Издательство: Springer
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Цена: 20962.00 р.
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Описание:

1. Tumor Staging and Grading: A Primer

Название: Metabolic Profiling: Disease and Xenobiotics
ISBN: 1849731632 ISBN-13(EAN): 9781849731638
Издательство: Royal Society of Chemistry
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Цена: 36960.00 р.
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Описание: This exemplary new book highlights applications of multivariate techniques in the areas of drug therapy and toxicology, cancer, obesity and diabetes, as well as outlining applications to cardiovascular, infectious, inflammatory and oral diseases in detail.

Автор: Simone Mocellin
Название: Microarray Technology and Cancer Gene Profiling
ISBN: 1441922989 ISBN-13(EAN): 9781441922984
Издательство: Springer
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Цена: 27951.00 р.
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Описание: Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated.

Автор: Binnig, Gerd Huss, Ralf Schmidt, Gunter
Название: Tissue phenomics: profiling cancer patients for treatment decisions
ISBN: 981477488X ISBN-13(EAN): 9789814774888
Издательство: Taylor&Francis
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Цена: 21284.00 р.
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Описание: In the age of digitization our society is transformed into a new state. In particular, machine intelligence dramatically elevates our capability to create and digest information. Naturally, healthcare is also impacted by this trend and will even be more transformed into a informatic driven discipline in the future. In the most important area of histo-pathology, the interpretation of tissue slices from cancer patients, informatics will have an early and huge impact on treatment decisions and probably will act as the leading discipline for this transformation in medicine. Tissue Phenomics provides a comprehensive methodology aiming at the discovery of the most accurate tissue-based decision support algorithm by close integration of assay development, image analysis and bioinformatics, and optimization feedback loops. In this book the methodology of Tissue Phenomics and its benefits and wealth’s are described. The different components of Tissue Phenomics are explained in the different chapters. In the chapters 2 to 4 of this book different authors describe various approaches on how to convert the wealth of tissue slide pixel data into mineable information using knowledge-based and data-driven image analysis methods. Subsequently, the datafication of images and the bioinformatics part plays a crucial role in generating prognostic and predictive models for disease progression. The integration of other data sources such as genomics, radiomics and patient related information is also important and is described as well. As discussed in chapters 5 and 6, these models may classify patients in distinct groups such as those responding to a given therapy. Since Tissue Phenomics provides a huge set of potentially prognostic features (phenes), one focus of both chapters is robust feature selection methods by advanced Monte-Carlo cross validation algorithms. In chapter 7 we discuss multiple application examples of Tissue Phenomics in academic and commercial settings and its tremendous impact to advances in biomedical sciences. Building on the successes in research, chapters 8 and 9 discuss applications in clinical environments and provide a flavor to the future envision in chapter 10, where tissue datafication and subsequent patient profiling is part of every routine examination, with the goal to best match patients with the most successful therapy, as predicted by tissue phenes.

Название: Risk Profiling in Genomics
ISBN: 0367356694 ISBN-13(EAN): 9780367356699
Издательство: Taylor&Francis
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Цена: 22202.00 р.
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Описание: This volume presents the ethical implications of risk information as related to genetics and other health data for policy decisions at clinical, research and societal levels. It will be of great interest to students and scholars of theoretical and clinical medical ethics, medical sociology, risk communication and ethics of risk.

Автор: Mathias Munschauer
Название: High-Resolution Profiling of Protein-RNA Interactions
ISBN: 3319368486 ISBN-13(EAN): 9783319368481
Издательство: Springer
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Цена: 14365.00 р.
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Описание: The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel `protein occupancy profiling` technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders.

Автор: Georgios A. Theodoridis; Helen G. Gika; Ian D. Wil
Название: Metabolic Profiling
ISBN: 149399252X ISBN-13(EAN): 9781493992522
Издательство: Springer
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Цена: 13275.00 р.
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Описание:

Автор: Virginia Espina; Lance A. Liotta
Название: Molecular Profiling
ISBN: 1493956841 ISBN-13(EAN): 9781493956845
Издательство: Springer
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Цена: 20962.00 р.
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Описание:

Contents

Preface

Contributors

1. Tumor Staging and Grading: A Primer

Stacy M. Cowherd

2. Clinical Trial Design in the Age of Molecular Profiling

Alexander Spira and Kirsten H. Edmiston

3. Personalized Medicine: Ethics for Clinical Trials

G. Terry Sharrer

4. Reduction of Preanalytical Variability in Specimen Procurement for Molecular Profiling

Virginia Espina and Claudius Mueller

5. The Human Side of Cancer Biobanking

Eoin Gaffney, Deirdre Madden, and Geraldine A. Thomas

6. Introduction to Genomics

Luca Del Giacco and Cristina Cattaneo

7. Genomic Profiling: cDNA arrays and oligoarrays

Francesco Gorreta, Walter Carbone, Dagania Barzhagi

8. Genome wide methylation profiling in archival formalin fixed paraffin embedded (FFPE) tissue samples

J. Keith Killian, Robert L. Walker, Sven Bilke, Yidong Chen, Sean Davis, Robert Cornelison, William I. Smith, and Paul S. Meltzer

9. An Overview of microRNA Methods: Expression Profiling and Target Identification

Sinйad M Smith and David W Murray

10. Antibody Validation by Western Blotting

Michele Signore and K. Alex Reeder

11. Laser Capture Microdissection: Arcturus^XT infra-red capture and UV cutting methods

Rosa I. Gallagher, Steven R. Blakely, Lance A. Liotta, and Virginia Espina

12. Antibody microarrays: Analysis of Cystic Fibrosis

Catherine E. Jozwik, Harvey B. Pollard, Meera Srivastava, Ofer Eidelman, QingYuan Fan, Thomas N. Darling, and Pamela L. Zeitlin

13. Tissue Microarrays As A Tool In The Discovery & Validation Of Predictive Biomarkers

Stephen M. Hewitt

14. Reverse phase protein microarrays

Mariaelena Pierobon, Francesca Galdi, Noemi Moroni, and Emanuel F. Petricoin III

15. Serum Low Molecular Weight Protein Fractionation for Biomarker Discovery

Amy VanMeter, Serena Camerini, Maria Letizia Polci, Alessandra Tessitore, Nishant Trivedi, Michael Heiby, Jonathan Hansen, and Weidong Zhou

16. Mass spectrometry based biomarker discovery

Weidong Zhou, Emanuel F. Petricoin III, and Caterina Longo

17. Mitochondrial Proteome: Toward The Detection and Profiling of Disease Associated Alterations

Paul C. Herrmann and E. Clifford Herrmann

18. Adult Neural Stem Cells: Isolation and Propagation

Jamin M. Lechter and Daniel N. Cox

19. Evanescent Wave Imaging: An Introduction to Total Internal Reflection Fluorescence Microscopy (TIRF)

Bryan A. Millis

20. Construction and Hyperspectral Imaging of Quantum Dot Lysate Arrays

Kevin P. Rosenblatt, Michael Huebschman, and Harold R. Garner

21. Microarray Data Analysis: Comparing Two Population Means

Jianghong Deng, Valerie S. Calvert and Mariaelena Pierobon

22. Bioinformatics/Biostatistics: microarray analysis

Gabriel S. Eichler

23. Structure-based functional design of drugs: from target to lead compound

Amy C. Anderson

24. Personalized Medicine: Changing the Paradigm of Drug Development

Robin Couch and Bryan T. Mott

25. Grant Writing Tips for the First Time Applicant

Lindsay Wescott and Michael Laskofski

26. Inventions and Patents: A practical tutorial

J. Lille Tidwell and Lance Liotta

27. Regulatory Approval Pathways for Molecular Diagnostic Technology

Lance Liotta and Emanuel Petricoin

28. Small business development for molecular diagnostics

Athanasia Anagnostou and Lance Liotta