Hedgehog Signaling: Methods and Protocols, Li Xiaochun

Автор: Ariel Ruiz i Altaba
Название: Hedgehog-Gli Signaling in Human Disease
ISBN: 1489989765 ISBN-13(EAN): 9781489989765
Издательство: Springer
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Цена: 26120.00 р.
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Описание: The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine.

Автор: Jingwu Xie
Название: Hedgehog signaling activation in human cancer and its clinical implications
ISBN: 1489995412 ISBN-13(EAN): 9781489995414
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics in humans. This volume provides insightful views suitable for clinical scientists, and graduate and undergraduate students alike.

Автор: Grutzmann Robert, Pilarsky Christian
Название: Cancer Gene Profiling: Methods and Protocols
ISBN: 1493979973 ISBN-13(EAN): 9781493979974
Издательство: Springer
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Цена: 15998.00 р.
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Описание:

1. Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository
Daniel S. Atherton, Katherine C. Sexton, Dennis Otali, Walter C. Bell, and William E. Grizzle

2. Tissue Microdissection
Anja Rabien and Glen Kristiansen

3. Tissue Microarrays
Ana-Maria Dancau, Ronald Simon, Martina Mirlacher, and Guido Sauter

4. Gene Expression Analysis in the Age of Mass Sequencing: An Introduction
Christian Pilarsky, Lahiri Kanth Nanduri, and Janine Roy

5. Quantitative DNA Methylation in Cancer
Ole Ammerpohl, Andrea Haake, Julia Kolarova, and Reiner Siebert

6. Single Nucleotide Polymorphism to Associate Cancer Risk
Victoria Shaw, Katie Bullock, and William Greenhalf

7: Exosomes in Cancer Disease
Margot Zцller

8: MicroRNAs (miRNAs) Profiling
Lu Gao and Feng Jiang

9. Cancer Gene Profiling for Response Prediction
B. Michael Ghadimi and Peter Jo

10. Target Gene Discovery for Novel Therapeutic Agents in Cancer Treatment
Sanjay Tiwari, Ole Ammerpohl, and Holger Kalthoff

11. Application of Proteomics in Cancer Biomarker Discovery: GeLC-MS/MS
Pedro R. Cutillas and Tatjana Crnogorac-Jurcevic

12. Meta-Analysis of Cancer Gene Profiling Data
Janine Roy, Christof Winter, and Michael Schroeder

13. Reproducible, Scalable Fusion Gene Detection from RNA-Seq
Vladan Arsenijevic and Brandi N. Davis-Dusenbery

14. Transcriptome Sequencing for the Detection of Chimeric Transcripts
Hsueh-Ting Chu

Автор: Greening David W., Simpson Richard J.
Название: Serum/Plasma Proteomics: Methods and Protocols
ISBN: 1493983806 ISBN-13(EAN): 9781493983803
Издательство: Springer
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Цена: 16769.00 р.
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Описание:

Part I Updated Blood Processing and Handling Strategies

1. Direct Assessment of Plasma/Serum Sample Quality for Proteomics Biomarker Investigation

Viviana Greco, Cristian Piras, Luisa Pieroni, and Andrea Urbani

2. A Protocol for the Preparation of Cryoprecipitate and Cryo-Depleted Plasma

Rosemary L Sparrow, David W Greening, and Richard J Simpson

3. A Proteomic Protocol for the Preparation of Platelet Concentrates

David W Greening, Richard J Simpson, and Rosemary L Sparrow

Part II Updated Fractionation Strategies for In-depth Blood Proteome Analysis

4. Bead-based and Multiplexed Immunoassays for Protein Profiling via Sequential Affinity Capture

Elin Birgersson, Jochen M. Schwenk, and Burcu Ayoglu

Автор: McGuckin Michael A., Thornton David J.
Название: Mucins: Methods and Protocols
ISBN: 1493958860 ISBN-13(EAN): 9781493958863
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Epithelial mucins are large complex cell surface and secreted glycoproteins produced by mucosal epithelial cells. In, Mucins: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study Mucins. These include methods and techniques for the best approaches to analysing each specific area of mucin biochemistry, physiology and biophysics before providing individual detailed experimental protocols together with troubleshooting and interpretation tips. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mucins: Methods and Protocols is designed to be a useful resource for those entering the mucin field and to facilitate those already studying mucins to broaden their experimental approaches to understanding mucosal biology.

Автор: Jamila I. Horabin
Название: Hedgehog Signaling Protocols
ISBN: 161737721X ISBN-13(EAN): 9781617377211
Издательство: Springer
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Цена: 21661.00 р.
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Описание: Intended for Molecular Biologists, Biochemists, and Geneticists interested in manipulating and analyzing the Hedgehog Signaling Pathway, this volume offers various detailed chapters on experimental description, including anecdotal pointers and notes.

Автор: Rubio Ignacio, Prior Ian
Название: Ras Activity and Signaling: Methods and Protocols
ISBN: 1071611895 ISBN-13(EAN): 9781071611890
Издательство: Springer
Цена: 18167.00 р.
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Описание: This volume compiles new experimental approaches and concepts focusing mostly, but not solely, on ways to manipulate and regulate Ras activity and its downstream signaling output.

Автор: Rubio Ignacio, Prior Ian
Название: Ras Activity and Signaling: Methods and Protocols
ISBN: 1071611925 ISBN-13(EAN): 9781071611920
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This volume compiles new experimental approaches and concepts focusing mostly, but not solely, on ways to manipulate and regulate Ras activity and its downstream signaling output.

Автор: Apte Suneel S.
Название: Adamts Proteases: Methods and Protocols
ISBN: 1493997009 ISBN-13(EAN): 9781493997008
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This volume provides a variety of methods used to analyze ADAMTS proteases and ADAMTS-like proteins, including their structure, substrate profile, tissue and cell distribution, post-translational modification and biological pathways. Chapters discuss genetic, cell biology, biochemical and proteomics techniques applicable to the analysis of all the members of the ADAMTS superfamily. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, ADAMTS Proteases: Methods and Protocols is a valuable tool for researchers to study both simple and sophisticated methodologies that are often difficult to locate in primary research literature.

Автор: Ursini-Siegel Josie, Beauchemin Nicole
Название: The Tumor Microenvironment: Methods and Protocols
ISBN: 1493981439 ISBN-13(EAN): 9781493981434
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis.

Автор: Kragelund Birthe B., Skriver Karen
Название: Intrinsically Disordered Proteins: Methods and Protocols
ISBN: 1071605232 ISBN-13(EAN): 9781071605233
Издательство: Springer
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Цена: 39130.00 р.
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Описание: The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims to help scientists with different backgrounds to further their investigations into these fascinating and dynamic molecules. Chapter 24 is available open access under a CC BY 4.0 license via link.springer.com. Chapters “40 and 42 ” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Автор: Robles-Flores Martha
Название: Cancer Cell Signaling: Methods and Protocols
ISBN: 1071607618 ISBN-13(EAN): 9781071607619
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This fully updated edition provides the most recent advances in cancer cell signaling knowledge combined with some discussion of the current challenges and prospects in cancer therapy.